BioTech — Research – NBN Sinhgad Techical Institutes Campus

DEPARTMENT OF BIOTECHNOLOGY

Research


Research Projects completed = 07 (Rs.68.98 Lakh)
Ongoing project = 02 (Rs. 30.6 Lakh)
Principal / Co-investigator = 04
Funding agency – DBT- SERB, AICTE, DHR-ICMR , BCUD (SPPU)

Research Projects and Funding


Sr. No.	Title of the Project	Name of Principal Investigator / Co investigator	Period of Project	Grant Sanctioned in (INR)	Name of the Funding Agency
1	Role of Ayurvedic Rasayana Pippali (Piper longum) in osteogenic differentiation of Human Umbilical Cord-derived Mesenchymal Stem Cells in 3D culture and diseased animal models.	Joshi Kalpana	2020-21	27.73	Science and Engineering Research Board, SERB, Government of India, New Delhi
2	Improving productivity of fragrances using fluidized bed Reactor	Kashid Shweta	2019-20	2.87	Assistance by SPPU for Project-based Innovative Research(ASPIRE),SPPU,Pune
3	A preliminary study to assess the role of Medhya Rasayana on proliferation and neurogenic differentiation using human stem cells as in vitro platform	Joshi Kalpana	2017-18	15.00	Tran disciplinary University (TDU), Bangalore
4	AICTE Adjunct Faculty Scheme	Joshi Kalpana	2017-18	6.00	AICTE Adjunct Faculty Grant Scheme
5	Exploring proliferative and differentiation potential of Ayurvedic Rasayanas using human umbilical cord derived Mesenchymal Stem Cells	Joshi Kalpana	2016-17	13.97	Science and Engineering Research Board, SERB, Department of Science and Technology, Government of India
6	Modernisation and Removal of Obsolescence Aicte(MODROB)	Joshi Kalpana	2016-17	14.50	AlI India Council of Technical Education AICTE
7	Novel method for Biofuel Production and Bio-separations using Deep Eutectic Solvents	Johle Prashant	2016-17	1.20	Board of College and University Development, SPPU, Pune
8	Bio-prospecting and optimization of extraction of trans Resveratrol: Commercially important anti-aging antioxidant polyphenol	Joshi Kalpana	2016-17	2.30	Board of College and University Development, SPPU, Pune
9	"Supplementation of vitamin B12 to improve BI12-folate ratio in pregnancy and its effect on birth outcome".	Joshi Kalpana	2016-17	16.01	Department of Health Research DHR-ICMR

Publication of Faculty in last Five Years


Sr. No.	Title of the Paper	Name of the Faculty	Name of the Journal	Year	DOI	Web of Science/Scopus
1	Exploring malted barley waste for fungi producing surface active proteins like hydrophobins	Shraddha Kulkarni, Kalpana S.Joshi, Sanjay Nene	SN Applied Sciences	2020-21	https://doi.org/10.1007/s42452-020-03696-w	Web of Science
2	Exploring AyuGenomics approach for understanding COVID-19 predisposition and progression	Kalpana Joshi	Journal of Ayurveda and Integrative Medicine (J-AIM)	2020-21	https://doi.org/10.1016/j.jaim.2021.06.003	Scopus
3	Mesenchymal stem cell conditioned medium ameliorates diabetic serum-induced insulin resistance in 3T3-L1 cells	Kalpana Joshi	Chronic Diseases and Translational Medicine	2020-21	https://doi.org/10.1016/J.CDTM.2020.09.001	Scopus
4	Exploring malted barley waste for fungi producing surface active proteins like hydrophobins	Kalpana S.Joshi, Shraddha S. Kulkarni, Sanjay Nene	SN Applied Sciences	2020-21	https://doi.org/10.1007/s42452-020-03696-w	Web of Science
5	Exploring malted barley waste for fungi producing surface active proteins like hydrophobins	Shraddha S. Kulkarni, Kalpana S.Joshi,Sanjay Nene	SN Applied Sciences	2020-21	https://doi.org/10.1007/s42452-020-03696-w
6	Pre-conditioning of Mesenchymal Stem Cells with Piper longum L. augments osteogenic differentiation	Kalpana Joshi	Journal of Ethnopharmacology	2020-21	https://doi.org/10.1016/j.jep.2021.113999	Scopus
7	A comparative study of production of hydrophobin like proteins (HYD-LPs) in submerged liquid and solid state fermentation from white rot fungus Pleurotus ostreatus	Shraddha S.Kulkarni, Sanjay N.Nene, Kalpana S.Joshi	Biocatalysis and Agricultural Biotechnology	2019-20	https://doi.org/10.1016/j.bcab.2019.101440	Scopus
8	Fabrication of enzyme‑based optical biosensor for estimation of inorganic phosphate in a urine sample	Sudha J. Kulkarni Meena S. Karve	SN Applied Sciences	2019-20	https://doi.org/10.1007/s42452-020-2748-6	Scopus
9	Two new polyoxygenated flavonoids from Blumea eriantha DC, methanol extract and their anti-proliferative activity	Kalpana Joshi	Natural Product Research	2019-20	https://doi.org/10.1080/14786419.2019.1672063	Scopus
10	Association of EGF A61G polymorphism and EGF expression	Kalpana Joshi	Gene Reports	2019-20	https://doi.org/10.1016/j.genrep.2019.100384	Scopus
11	Evaluation of the combinatorial effect of Tinospora cordifolia and Zingiber officinale on human breast cancer cells	Kalpana Joshi	3 Biotech	2019-20	https://doi.org/10.1007/s13205-019-1930-2	Scopus
12	6 α-Hydroxy-4[14], 10[15]-guainadien-8β, 12-olide induced cell cycle arrest via modulation of EMT and Wnt/β-catenin pathway in HER-2 positive breast cancer cells	Kalpana Joshi	The Journal of Steroid Biochemistry and Molecular Biology	2019-20	https://doi.org/10.1016/j.jsbmb.2019.105514	Scopus
13	Conditioned medium of adipose derived Mesenchymal Stem Cells reverse insulin resistance through downregulation of stress induced serine kinases	Kalpana Joshi	European Journal of Pharmacology	2019-20	https://doi.org/10.1016/j.ejphar.2020.173215	Scopus
14	Comparative Proteomics Unravels the Differences in Salt Stress Response of Own-Rooted and 110R-Grafted Thompson Seedless Grapevines	Manisha Shinde	Journal of Proteome Research – ACS Publications	2019-20	https://doi.org/10.1021/acs.jproteome.9b00420	Scopus
15	Fabrication of enzyme‑based optical biosensor for estimation of inorganic phosphate in a urine sample	Sudha J. Kulkarni	SN Applied Sciences	2019-20	https://doi.org/10.1007/s42452-020-2748-6	Scopus
16	A comparative study of production of hydrophobin like proteins (HYD-LPs) in submerged liquid and solid state fermentation from white rot fungus Pleurotus ostreatus	Kalpana S.Joshi, Shraddha S.Kulkarni, Sanjay Nene	Biocatalysis and Agricultural Biotechnology	2019-20	https://doi.org/10.1016/j.bcab.2019.101440	Scopus
17	A comparative study of production of hydrophobin like proteins (HYD-LPs) in submerged liquid and solid state fermentation from white rot fungus Pleurotus ostreatus	Shraddha Kulkarni, Kalpana S.Joshi, Sanjay Nene	Biocatalysis and Agricultural Biotechnology	2019-20	https://doi.org/10.1016/j.bcab.2019.101440
18	Association of EGF A61G polymorphism and EGF expression with type 2 diabetes mellitus in Indian population	Kalpana Joshi	Gene Reports	2019-20	https://doi.org/10.1016/j.genrep.2019.100384
19	A comparative study of production of hydrophobin like proteins (HYD-LPs) in submerged liquid and solid state fermentation from white rot fungus Pleurotus ostreatus	Shraddha S.Kulkarni, Kalpana S.Joshi	Biocatalysis and Agricultural Biotechnology	2019-20	https://doi.org/10.1016/j.bcab.2019.101440
20	Fabrication of enzyme‑based optical biosensor for estimation of inorganic phosphate in a urine sample	Sudha J. Kulkarni	SN Applied Sciences	2019-20	https://doi.org/10.1007/s42452-020-2748-6
21	Two new polyoxygenated flavonoids from Blumea eriantha DC, methanol extract and their anti-proliferative activity	Kalpana Joshi	Natural Product Research	2019-20	https://doi.org/10.1080/14786419.2019.1672063
22	Association of EGF A61G polymorphism and EGF expression with type 2 diabetes mellitus in Indian population	Kalpana Joshi	Gene Reports	2019-20	https://doi.org/10.1016/j.genrep.2019.100384
23	Evaluation of the combinatorial effect of Tinospora cordifolia and Zingiber officinale on human breast cancer cells	Kalpana Joshi	3 Biotech	2019-20	https://doi.org/10.1007/s13205-019-1930-2
24	6 α-Hydroxy-4[14], 10[15]-guainadien-8β, 12-olide induced cell cycle arrest via modulation of EMT and Wnt/β-catenin pathway in HER-2 positive breast cancer cells	Kalpana Joshi	The Journal of Steroid Biochemistry and Molecular Biology	2019-20	https://doi.org/10.1016/j.jsbmb.2019.105514
25	Conditioned medium of adipose derived Mesenchymal Stem Cells reverse insulin resistance through downregulation of stress induced serine kinases	Kalpana Joshi	European Journal of Pharmacology	2019-20	https://doi.org/10.1016/j.ejphar.2020.173215
26	Comparative Proteomics Unravels the Differences in Salt Stress Response of Own-Rooted and 110R-Grafted Thompson Seedless Grapevines	Manisha Shinde	Journal of Proteome Research – ACS Publications	2019-20	https://doi.org/10.1021/acs.jproteome.9b00420
27	PEG-200 Assisted Sonochemical synthesis of cerium (Ce3+) doped copper Oxide (CuO) Nano-composites and Their Photocatalytic Activities	Prashnt Jolhe	American Journal of Materials Synthesis and Processing	2018-19	http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=150&doi=10.11648/j.ajmsp.20170206.15	Web of Science
28	Variation in the Plasma Levels of Polyunsaturated Fatty Acids in Control vis-à-vis Nonalcoholic Fatty Liver Disease Subjects and Its Possible Association with Gut Microbiome	Kalpana Joshi	Metabolic Syndrome and Related Disorders	2018-19	https://doi.org/10.1089/met.2018.0008	Scopus
29	Anti-hyperglycemic and antihyperlipidaemic effect of Arjunarisht in high-fat fed animals	Kalpana Joshi	Journal of Ayurveda and Integrative Medicine	2018-19	https://doi.org/10.1016/j.jaim.2017.07.004	Scopus
30	Dietary pattern regulates fatty acid desaturase 1 gene expression in Indian pregnant women to spare overall long chain polyunsaturated fatty acids levels	Kalpana Joshi	Molecular Biology Reports	2018-19	https://doi.org/10.1007/s11033-018-4524-x	Scopus
31	Phytochemical characterization of ayurvedic formulations of Terminalia arjuna: A potential tool for quality assurance	Kalpana Joshi	Indian Journal of Traditional Knowledge	2018-19	http://nopr.niscair.res.in/bitstream/123456789/45674/3/IJTK%2018%281%29%20127-132.pdf	Scopus
32	Global transcriptome analysis of grapevine (Vitis vinifera L.) leaves under salt stress reveals differential response at early and late stages of stress in table grape cv. Thompson Seedless	Manisha Shinde	Plant Physiology and Biochemistry	2018-19	https://doi.org/10.1016/j.plaphy.2018.05.032	Scopus
33	Phytochemical characterization of ayurvedic formulations of Terminalia arjuna: A potential tool for quality assurance	Kalpana Joshi	Indian Journal of Traditional Knowledge	2018-19	http://nopr.niscair.res.in/bitstream/123456789/45674/3/IJTK%2018%281%29%20127-132.pdf
34	Ultrasound Assisted Synthesis of Performic Acid in a Continuous Flow Microstructured Reactor	Prashnt Jolhe	Ultrasonic Sonochemistry	2017-18	http://dx.doi.org/10.1016/j.ultsonch.2017.03.059	SCI
35	Process Intensification for Continuous Synthesis of Performic Acid Using Corning® Advanced-FlowTM Reactors	Prashnt Jolhe	Green Processing and Synthesis	2017-18	https://doi.org/10.1515/gps-2016-0147	Scopus
36	Production of Hydrophobins	Shraddha S. Kulkarni, Kalpana S.Joshi, Sanjay Nene	Process Biochemistry	2017-18	https://doi.org/10.1016/j.procbio.2017.06.012	Scopus
37	Gene polymorphisms of desaturase enzymes of polyunsaturated fatty acid metabolism and adiponutrin and the increased risk of nonalcoholic fatty liver disease	Kalpana Joshi	Meta Gene	2017-18	https://doi.org/10.1016/j.mgene.2016.08.009	Scopus
38	Herbal pre-conditioning induces proliferation and delays senescence in Wharton’s Jelly Mesenchymal Stem Cells	Kalpana Joshi	Biomedicine and Pharmacotherapy	2017-18	https://doi.org/10.1016/j.biopha.2017.06.107	Scopus
39	HLA-DRB1 class II alleles in Indian asthmatic population: A candidate gene environment interaction	Kalpana Joshi	Meta Gene	2017-18	http://dx.doi.org/10.1016/j.mgene.2017.08.001	Scopus
40	Combination of Vitamin B12 active forms improved foetal growth in Wistar rats through up-regulation of placental miR-16 and miR-21 levels	Kalpana Joshi	Life Science	2017-18	https://doi.org/10.1016/j.lfs.2017.10.017	Scopus
41	Halloysite nanocontainers for controlled delivery of Gibberellic Acid	Prashnt Jolhe	Russian Journal of Applied Chemistry	2017-18	http://dx.doi.org/10.1134/S1070427217010189	Scopus
42	Association of delta-6-desaturase enzyme activity and FADS gene polymorphisms with non-alcoholic fatty liver disease	Kalpana Joshi	Journal Of Gastroenterology And Hepatology	2017-18	NA	Scopus
43	Production of Hydrophobins	Kalpana S.Joshi, Shraddha S. Kulkarni, Sanjay N.Nene	Process Biochemistry	2017-18	https://doi.org/10.1016/j.procbio.2017.06.012	Scopus
44	Herbal pre-conditioning induces proliferation and delays senescence in Wharton’s Jelly Mesenchymal Stem Cells	Kalpana S.Joshi, Shraddha S. Kulkarni, Sanjay N.Nene	Biomedicine and Pharmacotherapy	2017-18	https://doi.org/10.1016/j.biopha.2017.06.107	Scopus
45	Herbal pre-conditioning induces proliferation and delays senescence in Wharton’s Jelly Mesenchymal Stem Cells	Kalpana Joshi	Biomedicine and Pharmacotherapy	2017-18	https://doi.org/10.1016/j.biopha.2017.06.107	Scopus
46	HLA-DRB1 class II alleles in Indian asthmatic population: A candidate gene environment interaction	Kalpana Joshi	Meta Gene	2017-18	http://dx.doi.org/10.1016/j.mgene.2017.08.001	Scopus
47	HLA-DRB1 class II alleles in Indian asthmatic population: A candidate gene environment interaction	Kalpana Joshi	Meta Gene	2017-18	http://dx.doi.org/10.1016/j.mgene.2017.08.001	Scopus
48	Immobilization of Saccharomyces Cerevisiae on novel matrix for ethanol production	Sudha Kulkarni , Mugdha Dicholkar	International Journal of Engineering Technology Science and Research	2017-18	http://www.ijetsr.com/images/short_pdf/1503911204_1157-1163-mccia944_ijetsr.pdf
49	Immobilization of Saccharomyces cerevisiae on Corn Cob Matrix for Ethanol Production	Sudha Kulkarni , Mugdha Dicholkar	International Journal of Engineering Technology Science and Research	2017-18	http://ijetsr.com/images/short_pdf/1510498819_111-116-ietep944_ijetsr.pdf
50	Immobilization of Saccharomyces Cerevisiae on novel matrix for ethanol production	Sudha Kulkarni , Mugdha Dicholkar	International Journal of Engineering Technology Science and Research	2017-18	http://www.ijetsr.com/images/short_pdf/1503911204_1157-1163-mccia944_ijetsr.pdf
51	Green Route for Silver Nanoparticles by Raphanus Sativus Extract in a Continuous Flow Tubular Microreactor, International Journal of Nanoscience	Prashant Jolhe	International Journal of Nanoscience	2016-17	http://dx.doi.org/10.1142/ S0219581X16500198	SCI
52	Positive selection on a regulatory insertion-deletion polymorphism in FADS2 influences apparent endogenous synthesis of arachidonic acid	Kalpana S. Joshi	Molecular biology and Evolution	2016-17	https://dx.doi.org/10.1093%2Fmolbev%2Fmsw049	Scopus
53	DNA methylation detection at single base resolution using targeted next generation bisulfite sequencing and cross validation using capillary sequencing	Kalpana S. Joshi	Gene	2016-17	https://doi.org/10.1016/j.gene.2016.09.019	Scopus
54	Molecular and cellular effects of vitamin B12 forms on human tropoblast cells in presence of excessive folate, Biomedicine and Pharmacotherapy	K. S. Joshi	Biomedicine and pharmacology	2016-17	https://doi.org/10.1016/j.biopha.2016.09.071	Scopus
55	Role of Spatial Inhomogenity in GPCR Dimerisation Predicted by Receptor Association-Diffusion Models	Deshpande, Sneha	IOP Science Physical Biology	2016-17	https://doi.org/10.1088/1478-3975/aa6b68

Patent Published in last five Years


Sr. No.	Name of theFaculty	Title	Status
1	Dr. Kalpana S. Joshi	A method for extractingGuaianolide from Cyathoclinepurpurea.	Approval No.-358075, Date-09/02/2021
2	Kalpana S. Joshi, Sudha J. Kulkarni	A Process for Extraction & Purification of Resveratrol	Published

Papers published in International Conferences with Students


Academic Year	Publication in International Conference
2016-17	04
2017-18	07
2018-19	10
2019-20	07
2020-21	02

Research Areas